Hereditary Disposition to Hemorrhage
نویسندگان
چکیده
منابع مشابه
Amyloid β in hereditary cerebral hemorrhage with amyloidosis-Dutch type.
Hereditary cerebral hemorrhage with amyloidosis - Dutch type is an autosomal dominant hereditary disease caused by a point mutation in the amyloid precursor protein gene on chromosome 21. The mutation causes an amino acid substitution at codon 693 (E22Q), the 'Dutch mutation'. Amyloid β, the product after cleavage of the amyloid precursor protein, is secreted into the extracellular space. The D...
متن کاملHereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.
Hereditary cerebral hemorrhage with amyloidosis in Dutch patients is an autosomal dominant form of vascular amyloidosis restricted to the leptomeninges and cerebral cortex. Clinically the disease is characterized by cerebral hemorrhages leading to an early death. Immunohistochemical studies of five patients revealed that the vascular amyloid deposits reacted intensely with an antiserum raised a...
متن کاملAbeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent cerebral hemorrhagic strokes and dementia. In contrast to Alzheimer disease (AD), the brains of those affected by hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) show few parenchymal amyloid plaques. We found that neuronal overexpression of human E693Q A...
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Hemophagocytic lymphohistiocytosis (HLH) is the result of excessive cytokine release, leading to over-response by immune cells, such as macrophages and T lymphocytes. Here, we report a lethal case of HLH with a complete clinical course. The patient was a 45-year-old man with fever and chills since two months ago plus splenomegaly, hepatomegaly, and pancytopenia. The Anti-HBc IgM was positive, b...
متن کاملGorenstein hereditary rings with respect to a semidualizing module
Let $C$ be a semidualizing module. We first investigate the properties of finitely generated $G_C$-projective modules. Then, relative to $C$, we introduce and study the rings over which every submodule of a projective (flat) module is $G_C$-projective (flat), which we call $C$-Gorenstein (semi)hereditary rings. It is proved that every $C$-Gorenstein hereditary ring is both cohe...
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ژورنال
عنوان ژورنال: The Boston Medical and Surgical Journal
سال: 1833
ISSN: 0096-6762,1533-4406
DOI: 10.1056/nejm183305150081403